A REVIEW OF PKRRATING

The activated enzyme then phosphorylates its significant substrate, the translational initiation issue eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to some conserved spouse and children of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in response to diverse stimuli12, triggering the in